Product Name: 1,3-Dichloroisopropanol
Chemical Formula: C3H6Cl2O
SYNONYMS: 1,3-Dichloro-2-propanol, 2-Propanol, 1,3-dichloro-
CAS Number: 96-23-1
Intended Use: Intermediate in organic and pharmaceutical synthesis
Supplier: Contact details of manufacturer or distributor with emergency phone number and address
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation), Skin Irritation, Serious Eye Irritation, Carcinogenicity, Potential Mutagenicity
Signal Word: Danger
Hazard Statements: Harmful if swallowed, in contact with skin, or if inhaled. Suspected of causing cancer. Causes skin and eye irritation. May cause genetic defects.
Pictograms: Skull & Crossbones, Exclamation Mark, Health Hazard
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Target Organs: Liver, kidneys, nervous system
Precautionary Statements: Do not breathe dust, vapors, or mist. Wear protective gloves, clothing, and eye protection. Wash hands thoroughly after handling. Avoid release into the environment.
Chemical Name: 1,3-Dichloroisopropanol
Chemical Formula: C3H6Cl2O
Concentration: >98%
Hazardous Impurities: May contain trace amounts of hydrochloric acid and related chlorinated substances
EC Number: 202-491-9
Inhalation: Move person to fresh air. If not breathing, give artificial respiration. Call physician immediately.
Skin Contact: Remove contaminated clothing. Rinse skin immediately with soap and water for no less than 15 minutes. Seek medical help.
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, hold eyelids open. Contact an ophthalmologist at once.
Ingestion: Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Get medical attention immediately.
Medical Notes: Treat symptomatically and supportively. Delayed effects from exposure are possible.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Media: Straight streams of water can spread chemical
Hazardous Combustion Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide
Special Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Fire/Explosion Hazards: Vapors may form explosive mixtures with air. Containers exposed to intense heat may rupture
Advice: Move containers away from fire area if this can be done safely. Cool with water spray.
Personal Precautions: Evacuate unnecessary personnel. Avoid inhalation or skin/eye contact. Use personal protective equipment.
Environmental Precautions: Keep away from drains and waterways. Prevent further spillage or leakage where possible.
Spill Cleanup Methods: Use inert absorbent material (sand, diatomaceous earth). Collect spill in suitable closed container for disposal. Ventilate area.
Decontamination: Wash site with plenty of water after material pick-up. Dispose of waste according to all regulations.
Notification: Report releases as required by local, regional, and national regulations.
Handling: Only handle inside well-ventilated areas or with exhaust ventilation. Use spark-proof tools and explosion-proof equipment. Avoid contact with skin, eyes, clothes.
Hygiene Practices: Wash hands and face after handling, before eating, and on completion of work.
Storage Conditions: Store in a cool, dry, well-ventilated place away from ignition sources. Protect from light and moisture.
Incompatible Materials: Strong bases, strong oxidizers, strong acids, alkali metals
Specific Precautions: Store in tightly closed containers labeled with hazard symbols. Prevent static discharge.
Exposure Limits: No OSHA PEL or ACGIH TLV established. Minimize exposure.
Engineering Controls: Local exhaust ventilation, chemical fume hood, eye wash stations, safety showers
Respiratory Protection: NIOSH-approved full-face respirator with organic vapor cartridge, especially if vapor levels exceed limits
Hand Protection: Impermeable gloves such as nitrile, neoprene, or rubber
Eye/Face Protection: Safety goggles, face shield if necessary
Skin/Bodily Protection: Chemical-resistant apron or laboratory coat, closed-toe shoes
Work Practices: Do not eat, drink, or smoke in work areas; remove contaminated clothing before leaving work area.
Appearance: Colorless to pale yellow liquid
Odor: Pungent, sharp, chloroform-like
Boiling Point: 174–175°C
Melting Point: -47°C
Flash Point: 80°C (closed cup)
Auto-ignition Temperature: 425°C
Vapor Pressure: 1.2 mmHg at 20°C
Solubility: Miscible with water, ethanol, diethyl ether
Density: 1.42 g/cm³ at 20°C
pH: Not applicable (neutral in solution)
Partition Coefficient (Log Kow): Approx. 1.2
Viscosity: Not measured
Decomposition Temperature: Not established
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Reacts with strong bases, strong alkalis, oxidants, and acids
Polymerization: No known hazardous polymerization
Hazardous Decomposition Products: Hydrogen chloride gas, phosgene, carbon oxides
Conditions To Avoid: Heat, open flames, sparks, static electricity, moisture, and direct sunlight
Incompatible Materials: Ammonia, alkali metals, strong oxidizing agents
Acute Toxicity: Oral LD50 (rat): 170 mg/kg. Inhalation causes respiratory irritation, CNS depression. Dermal exposure may result in irritation or absorption and systemic toxicity.
Chronic Effects: Classified as carcinogenic (IARC Group 2B). Evidence of mutagenicity and teratogenicity.
Eye/Skin Effects: Severe irritation, possible eye burns, redness, or blisters on skin
Respiratory Effects: Inhalation may cause coughing, dizziness, headache, nausea, unconsciousness at high concentrations
Target Organs: Liver, kidneys, nervous system
Sensitization: No data indicating skin or respiratory sensitization reported
Other Effects: Prolonged exposure may result in hepatic and renal dysfunction.
Aquatic Toxicity: Harmful to aquatic organisms. Data indicate LC50 (fish, 96h): 10–100 mg/L
Persistence & Degradability: Moderately biodegradable. May persist in some conditions.
Bioaccumulation: Low to moderate bioaccumulative potential (Log Kow 1.2)
Mobility in Soil: High water solubility may allow leaching into groundwater
Other Information: Avoid uncontrolled release into the environment. Not classified as highly toxic but poses long-term risk with repeated spillages.
Regulatory Status: Subject to international environmental regulations (e.g., REACH, EPA).
Waste Disposal Methods: Incinerate with proper emission controls where permitted by national/state legislation. Do not pour down drains or sewers.
Container Disposal: Triple rinse, then dispose of container as hazardous waste.
Local Regulations: Comply with all federal, state, and local environmental control regulations.
Special Precautions: Use trained, licensed hazardous waste disposal companies. Keep all documentation for tracking and legal compliance.
UN Number: 2689
Shipping Name: 1,3-Dichloroisopropanol
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II (Medium danger)
Labels: Toxic, Environmental Hazard (as required)
Special Precautions: Shipping containers must be secure, labeled, and protected from damage or leaks. Emergency response guides should be accessible during transport.
Transportation Regulations: Adhere to ADR/RID, IMDG, ICAO/IATA coding for hazardous goods by road, sea, and air
Additional Notes: Report any large quantity spillages or transport incidents to appropriate authorities immediately.
Regulatory Status: Listed by national and international chemical inventories. Subject to workplace safety, hazardous chemical, and environmental regulations under U.S. OSHA, European REACH, and comparable agencies.
OSHA: Regulated hazardous substance
TSCA: Listed
REACH Registration: Required in the European Union
Labeling: GHS and EU directive labels showing relevant hazard statements, pictograms, and precautionary statements are mandatory.
SARA Title III: Listed (Section 313)
Other International Regulations: Possible restrictions for use, import, or production imposed depending on local jurisdiction requirements.
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