MSDS for 1,2-Propanediol, 3-amino-, (2R)-

1. Identification

Product Name: 1,2-Propanediol, 3-amino-, (2R)-
Chemical Formula: C3H9NO
Synonyms: (R)-3-Amino-1,2-propanediol, (2R)-3-Aminopropane-1,2-diol
CAS Number: 616-29-5
Manufacturer: Refer to supplier’s contact list or purchase source
Recommended Uses: Chemical synthesis, pharmaceutical intermediate, specialty chemical
Supplier Contact: Manufacturer’s emergency line; 24-hour transportation contact details

2. Hazard Identification

GHS Classification: Eye irritation: Category 2A, Skin irritation: Category 2
Signal Word: Warning
Hazard Statements: Causes serious eye irritation. Causes skin irritation. May cause respiratory irritation if inhaled.
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, vapors, or mist. Use only outdoors or in well-ventilated areas. Wear protective gloves, eye protection, and suitable clothing.

3. Composition / Information on Ingredients

Chemical Name: (2R)-3-Aminopropane-1,2-diol
Concentration: >99% (pure substance)
Impurities: Trace moisture, minor by-products from synthesis
Trade Secret: None disclosed
Other Components: Not applicable for single-compound materials

4. First Aid Measures

Eye Contact: Immediately flush with running water for at least 15 minutes, keeping eyelids open. Remove contact lenses if present and easy to do.
Skin Contact: Wash affected area with soap and water, remove contaminated clothing and shoes, seek medical attention for persistent irritation.
Inhalation: Move person to fresh air, keep comfortable for breathing, seek medical attention for symptoms like coughing, difficulty breathing, or throat irritation.
Ingestion: Rinse mouth, do not induce vomiting, give water if conscious, seek prompt medical assistance.
Most Important Symptoms: Eye redness, stinging, dryness, skin discomfort, sore throat, coughing
Immediate Medical Attention: Recommended when adverse reactions persist beyond basic first aid

5. Fire-Fighting Measures

Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Special Hazards: May produce hazardous fumes such as nitrogen oxides, carbon monoxide, and carbon dioxide during combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Advice for Firefighters: Use caution, do not allow contaminated runoff to enter waterways, keep containers cool with water spray to prevent rupture.

6. Accidental Release Measures

Personal Precautions: Wear protective gloves, clothing, goggles, avoid skin and eye contact, ensure good ventilation or respiratory protection if needed
Emergency Procedures: Evacuate unnecessary personnel, keep area well-ventilated, restrict access
Spill Cleanup: Absorb with inert material such as sand or earth, collect in suitable labeled containers for disposal, wash spill area with large volumes of water, prevent spill from entering drains or waterways
Environmental Precautions: Do not discharge into the environment or natural waters

7. Handling and Storage

Safe Handling: Utilize personal protective equipment, avoid skin and eye contact, avoid release to environment, prevent dust or mist formation
Storage Conditions: Store tightly closed at 2-8°C in a dry, ventilated area, away from oxidizers, acids, or incompatible materials
Special Considerations: Keep container dry, labeled and securely closed. Isolate from food and drink.
Incompatible Materials: Strong acids, oxidizing agents

8. Exposure Controls and Personal Protection

Occupational Exposure Limits: No established regulatory exposure limits; use general dust/mist control guidelines
Engineering Controls: Ensure adequate local exhaust ventilation at points of dust generation or mist formation
Personal Protective Equipment (PPE): Chemical-resistant gloves, safety goggles, lab coats or aprons, respiratory protection for insufficient ventilation
Hygiene Measures: Wash hands before eating or drinking, remove contaminated clothing before entering communal areas

9. Physical and Chemical Properties

Appearance: Colorless to pale yellow solid or liquid, depending on temperature
Odor: Mild, amine-like
Molecular Weight: 75.11 g/mol
Boiling Point: Approx. 205°C
Melting Point: 46-48°C
Solubility: Soluble in water
pH: Neutral to slightly basic (solution)
Vapor Pressure: Low, non-volatile under ambient conditions
Flash Point: Above 100°C (closed cup)

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Extremes of temperature, direct sunlight, moisture exposure, sources of ignition
Incompatible Substances: Strong oxidizers, acids, reducing agents
Hazardous Decomposition Products: Nitrogen oxides, ammonia, carbon oxides released during burning or decomposition
Polymerization: Will not occur under normal conditions

11. Toxicological Information

Acute Toxicity: Likely moderate; oral and dermal toxicity levels not well documented
Irritation: Causes moderate eye and skin irritation, may irritate respiratory tract
Sensitization: Low risk of skin sensitization, but not entirely ruled out
Chronic Effects: No chronic toxicity data available; not recognized as carcinogenic, mutagenic, or toxic to reproduction
Routes of Exposure: Inhalation, dermal, ingestion, eye contact
Symptoms: Redness, dryness, discomfort or pain at contact points

12. Ecological Information

Ecotoxicity: No specific data, should avoid uncontrolled release to aquatic systems
Persistence and Degradability: Expected to be biodegradable based on structure
Bioaccumulation: Low potential due to water solubility and molecular size
Mobility in Soil: May leach to groundwater if released in large quantities
Other Adverse Effects: No evidence of significant harm but prudent to minimize environmental exposure

13. Disposal Considerations

Disposal Methods: Collect in suitable containers for chemical waste; incinerate if permitted, or contract licensed chemical disposal service
Waste Classification: Not listed as hazardous waste under federal regulations, but assess per local guidelines
Contaminated Packaging: Triple rinse and dispose as chemical waste
Precautions: Do not release into sewer or natural environment, follow official guidance

14. Transport Information

UN Number: Not classified as dangerous by current transport standards
Transport Class: Not regulated for land, sea, or air logistics under common criteria
Packing Group: Not applicable
Proper Shipping Name: Chemical substance, not otherwise specified
Special Precautions: Protect from rough handling, avoid unnecessary exposure during loading and unloading

15. Regulatory Information

TSCA Status: Listed or meets TSCA requirements
REACH Registration: Exempt or registered depending on annual tonnages
SARA Title III Sections 302/304: Not listed
SARA 313: Not listed as a toxic chemical
California Prop 65: Not listed
Other International Inventories: Refer to National Chemical Inventories of target country
Labeling Requirements: Follow OSHA Hazard Communication Standard for labeling and workplace communication