Calcium Gluconate

Calcium Gluconate Uses
1. As a food additive, used as a buffer; curing agent; a chelating agent; nutritional supplement. According to the “Hygienic Standards for the Use of Food Nutrition Fortifiers” (1993) promulgated by the Ministry of Health of my country, it can be used in cereals and their products, beverages, and the dosage is 18-38 grams, kg.
2. As a drug, it can reduce capillary permeability, increase density, maintain normal excitability of nerves and muscles, strengthen myocardial contractility, and help bone formation. It is suitable for allergic diseases, such as urticaria; eczema; skin pruritus; contact dermatitis, and serum sickness; angioedema as an adjuvant treatment. It is also suitable for convulsions and magnesium poisoning caused by hypocalcemia. It is also used to prevent and treat calcium deficiency.

Calcium gluconate belongs to organic acid calcium and is mainly used for the prevention and treatment of calcium deficiency (such as osteoporosis, osteomalacia, rickets and calcium supplementation for children, pregnant and lactating women, menopausal women, and the elderly) and acute blood Hypocalcemia, alkalosis, and tetany due to hypoparathyroidism. Other uses are as follows:
1. Acute hypocalcemia is a serum calcium concentration lower than 2mmol/L. Active intravenous calcium supplementation is required in cases of acute hypocalcemia such as tetany, seizures, and laryngospasm. It is recommended to slowly inject 10-20ml of 10% calcium gluconate intravenously, no more than 5ml per minute, which can usually make the symptoms disappear immediately; if the symptoms recur, the administration can be repeated several hours later. 2. Hypermagnesemia Hypermagnesemia refers to serum magnesium higher than 1.25mmol/L. Hypermagnesemia mainly occurs in patients with renal dysfunction. Long-term use of magnesium-containing antacids, magnesium sulfate catharsis, especially in patients with renal impairment, can lead to hypermagnesemia. In addition, hypermagnesemia is not uncommon with intravenous magnesium sulfate to treat preeclampsia. Treatment of mild hypermagnesemia is usually to limit magnesium intake. For patients with severe hypermagnesemia, it is recommended to slowly inject 10ml of 10% calcium gluconate injection to antagonize the effect of magnesium on the heart and neuromuscular system.
3. Hyperkalemia Hyperkalemia refers to serum potassium > 5.5mmol/L. Renal failure is a common cause of hyperkalemia, and potassium-sparing diuretics, cyclosporine, NSAIDs, ACEI, ARB, etc., can also cause hyperkalemia. Hyperkalemia mainly affects the heart, including ECG abnormalities, ventricular arrhythmias, and cardiac arrest. If hyperkalemia affects the heart, the primary treatment is intravenous 10% calcium gluconate injection 10ml. Calcium gluconate is usually injected slowly, and then the dose is adjusted according to the improvement of the ECG.